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Comparison of the 2019 European Alliance of Associations for Rheumatology/American College of Rheumatology Systemic Lupus Erythematosus Classification Criteria With Two Sets of Earlier Systemic Lupus Erythematosus Classification Criteria

Petri, Michelle (author)
Johns Hopkins University
Goldman, Daniel W. (author)
Johns Hopkins University
Alarcón, Graciela S. (author)
University of Alabama
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Gordon, Caroline (author)
University of Birmingham
Merrill, Joan T. (author)
Oklahoma Medical Research Foundation
Fortin, Paul R. (author)
Laval University
Bruce, Ian N. (author)
Manchester University NHS Foundation Trust
Isenberg, David (author)
University College London
Wallace, Daniel (author)
University of California, Los Angeles
Nived, Ola (author)
Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
Ramsey-Goldman, Rosalind (author)
Northwestern University
Bae, Sang Cheol (author)
Hanly, John G. (author)
Dalhousie University
Sanchez-Guerrero, Jorge (author)
University of Toronto
Clarke, Ann E. (author)
University of Calgary
Aranow, Cynthia (author)
Feinstein Institute for Medical Research
Manzi, Susan (author)
Allegheny Health Network
Urowitz, Murray (author)
University of Toronto
Gladman, Dafna D. (author)
University of Toronto
Kalunian, Ken (author)
University of California, San Diego
Werth, Victoria P. (author)
Hospital of the University of Pennsylvania
Zoma, Asad (author)
Hairmyres Hospital
Bernatsky, Sasha (author)
McGill University Health Center
Khamashta, Munther (author)
Jacobsen, Søren (author)
Copenhagen University Hospital
Buyon, Jill P. (author)
New York University
Dooley, Mary Anne (author)
University of North Carolina
van Vollenhoven, Ronald (author)
Academic Medical Center of University of Amsterdam (AMC)
Ginzler, Ellen (author)
SUNY Downstate Health Sciences University
Stoll, Thomas (author)
Cantonal Hospital of Olten
Peschken, Christine (author)
University of Manitoba
Jorizzo, Joseph L. (author)
Wake Forest University
Callen, Jeffery P. (author)
University of Louisville
Lim, Sam (author)
Emory University
Inanç, Murat (author)
Istanbul University
Kamen, Diane L. (author)
Medical University of South Carolina
Rahman, Anisur (author)
University College London
Steinsson, Kristjan (author)
National University Hospital of Iceland
Franks, Andrew G. (author)
New York University
Magder, Laurence S. (author)
University of Maryland, Baltimore
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 (creator_code:org_t)
2021-07-14
2021
English 5 s.
In: Arthritis Care and Research. - : Wiley. - 2151-464X .- 2151-4658. ; 73:9, s. 1231-1235
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Objective: The Systemic Lupus International Collaborating Clinics (SLICC) 2012 systemic lupus erythematosus (SLE) classification criteria and the revised American College of Rheumatology (ACR) 1997 criteria are list based, counting each SLE manifestation equally. We derived a classification rule based on giving variable weights to the SLICC criteria and compared its performance to the revised ACR 1997, the unweighted SLICC 2012, and the newly reported European Alliance of Associations for Rheumatology (EULAR)/ACR 2019 criteria sets. Methods: The physician-rated patient scenarios used to develop the SLICC 2012 classification criteria were reemployed to devise a new weighted classification rule using multiple linear regression. The performance of the rule was evaluated on an independent set of expert-diagnosed patient scenarios and compared to the performance of the previously reported classification rules. Results: The weighted SLICC criteria and the EULAR/ACR 2019 criteria had less sensitivity but better specificity compared to the list-based revised ACR 1997 and SLICC 2012 classification criteria. There were no statistically significant differences between any pair of rules with respect to overall agreement with the physician diagnosis. Conclusion: The 2 new weighted classification rules did not perform better than the existing list-based rules in terms of overall agreement on a data set originally generated to assess the SLICC criteria. Given the added complexity of summing weights, researchers may prefer the unweighted SLICC criteria. However, the performance of a classification rule will always depend on the populations from which the cases and non-cases are derived and whether the goal is to prioritize sensitivity or specificity.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

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